Experimental and Theoretical Investigation into the Thermal Conductivity and Heating-Softening Bending of Glass-Fiber-Reinforced Polypropylene Rebars.

Thermoplastic fiber-reinforced polymer (FRP) reinforcement has a significant advantage over traditional thermosetting FRP reinforcements in that it can be bent on site by heating-softening processing. However, current experimental and theoretical research on the thermal conductivity and heating-softening processing characteristics of thermoplastic FRP reinforcements is quite insufficient. Through heating-softening processing tests, numerical simulation, and theoretical calculation, this study investigated the heating-softening processing time of a thermoplastic glass-fiber-reinforced polypropylene (GFRPP) reinforcement.

A Latent Class Analysis of Resilience and Its Relationship With Care Burden and Psychological Distress in Family Caregivers of Older Adults With Disability.

Given the challenging circumstances of aging with disability, family caregivers (FGs) face significant strain. Resilience, however, is a crucial protective factor against adverse caregiving outcomes. The study thus aimed to determine the latent classes of resilience among FGs and examine how these classes are related to care burden and psychological distress.

Association and interaction between resilience and psychological distress in disabled elderly-caregiver dyads: An actor-partner interdependence model.

Objectives: This study examined the association and interaction between resilience and psychological distress in disabled elderly-caregiver dyads.

Methods: A total of 246 disabled elderly individuals and their family caregivers were studied using the Resilience Scale and the Distress Thermometer and Problem List. The data analysis employed the actor-partner interdependence model (APIM) method based on structural equation modelling.

Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer.

Conventional neoadjuvant chemotherapy provides limited benefit for patients with resectable non-small cell lung cancer (NSCLC). Recently, neoadjuvant chemoimmunotherapy (NCIT) has transformed the perioperative management of NSCLC by priming systemic anti-tumor immunity before surgery, yet it remains ineffective for at least 50% of patients. Through single-cell sequencing analysis of our NCIT cohort, we identify that antigen-presenting cancer-associated fibroblasts (apCAFs) can impede the efficacy of NCIT.

Mental health literacy among older adults in Shanghai: a descriptive qualitative study.

Background: The aging population in China is surging rapidly, and elderly individuals are at higher risk of multiple mental health issues. Improving the mental health literacy of older adults can help them recognize mental illness and adopt proactive measures, potentially improving their mental health status and supporting the goal of healthy aging.

Objective: To explore mental health literacy among older adults, providing a foundation for future interventions aimed at improving their mental health literacy.

Introducing the Sisu Voice Matching Test (SVMT): A novel tool for assessing voice discrimination in Chinese.

Existing standardized tests for voice discrimination are based mainly on Indo-European languages, particularly English. However, voice identity perception is influenced by language familiarity, with listeners generally performing better in their native language than in a foreign one. To provide a more accurate and comprehensive assessment of voice discrimination, it is crucial to develop tests tailored to the native language of the test takers.

Validation of the Maslach burnout inventory-general survey 9-item short version (MBI-GS9) among care aides in Canadian nursing homes.

Background: The Maslach Burnout Inventory-General Survey (MBI-GS) is the leading measure of burnout for all occupations. The MBI-GS9, the 9-item version of the MBI-GS, was formulated based on the MBI-GS and has been used for several years. However, very few studies have systematically tested its psychometric properties, and none have focused on care aides working in nursing homes who are susceptible to burnout.

Examining factorial validity and internal consistency of Professional Quality of Life (ProQoL-9) among care aides working in Long-term Care (LTC).

Background: The ProQoL (30 items) is a widely used instrument of work-related quality of life for health care workers. Recently, a shorter 9-item version of the ProQoL was developed and validated among palliative care workers. The ProQoL-9 consists of three subscales: compassion satisfaction (CS), burnout (BO), and compassion fatigue (CF).

Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip.

Here, we present a bioengineering approach to emulate the human bone marrow in vitro. Our developmentally inspired method uses self-organization of human hematopoietic stem and progenitor cells and vascular endothelial cells cultured in a three-dimensional microphysiological system to create vascularized, perfusable tissue constructs that resemble the hematopoietic vascular niche of the human marrow. The microengineered niche is capable of multilineage hematopoiesis and can generate functionally mature human myeloid cells that can intravasate into perfused blood vessels, providing a means to model the mobilization of innate immune cells from the marrow.

Dissociation in Long-Term Care Home Staff During COVID-19: Challenges and Promising Practices.

Objectives: Long-term care (LTC) staff may develop dissociation due to high-stress work environments and trauma exposures. This study aimed to (1) assess the prevalence of pathological dissociation in LTC home staff during the COVID-19 pandemic; (2) examine the associations of pathological dissociation with demographic characteristics, mental health, insomnia, and professional quality of life; and (3) examine whether pathological dissociation was sensitive to change following a coherent breathing intervention.

Design: We analyzed data from a pre-post breathing intervention study conducted between January and September 2022.

Among-Population Differentiation in the Tapeworm Proteome through Prediction of Excretory/Secretory and Transmembrane Proteins in .

Background: Parasites secrete and excrete a variety of molecules evolve to help establish and sustain infections within hosts. Parasite adaptation to their host may lead to between-population divergence in these excretory and secretory products (ESPs), but few studies have tested for intraspecific variation in helminth proteomes.

Methods: is a cestode that parasitizes three spined stickleback, .

Senescence-associated secretory phenotype regulation by dual drug delivery biomimetic nanoplatform for enhanced tumor chemotherapy.

Many chemotherapies, which are still the main clinical treatment for primary tumors, will induce persistent DNA damage in non-tumor stromal cells, especially cancer-associated fibroblasts (CAFs), and activate them to secrete senescence-associated secretory phenotype (SASP). The transition could further result in the formation of tumor immunosuppressive microenvironment and cause drug resistance of neighboring tumor cells. To solve this dilemma, a multi-functional biomimetic drug delivery system (named mPtP@Lipo) was rationally developed by combining CAFs reshaper ginsenoside 20(S)-protopanaxadiol (PPD) and cisplatin prodrug (PtLA) to inhibit tumor progression and the formation of SASP.

High-Density Genetic Map Construction and Quantitative Trait Locus Analysis of Fruit- and Oil-Related Traits in Based on Double Digest Restriction Site-Associated DNA Sequencing.

, an important tree species and source of edible oil in China, has received significant attention owing to the oil's high unsaturated fatty acid content, which has benefits for human health. However, the mechanisms underlying yield and oil quality are largely unknown. In this study, 180 F progenies were obtained from two parents with obvious differences in fruit- and oil-related traits.

Analysis of the Tensile Properties and Probabilistic Characteristics of Large-Tow Carbon Fiber-Reinforced Polymer Composites.

Large-tow carbon fiber-reinforced polymer composites (CFRP) have great application potential in civil engineering due to their low price, but their basic mechanical properties are still unclear. The tensile properties of large-tow CFRP rods and plates were investigated in this study. First, the tensile properties of unidirectional CFRP rods and plates were studied, and the test results of the relevant mechanical properties were statistically analyzed.

Pathological complete response to neoadjuvant lorlatinib in a patient with stage IIIA -positive non-small cell lung cancer: a case report.

Background: Given the promising efficacy of targeted therapies in patients with advanced non-small cell lung cancer (NSCLC) harboring oncogenic drivers, its use in adjuvant and even neoadjuvant therapy is increasing. Lorlatinib is a potent brain-penetrating third-generation anaplastic lymphoma kinase () and c-ros oncogene 1, receptor tyrosine kinase () tyrosine kinase inhibitors (TKIs) with broad mutation coverage. Currently, there is a limited evidence regarding the efficacy of lorlatinib as neoadjuvant therapy in locally advanced NSCLC in the presence of rearrangements.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure.

The small molecule epiberberine (EPI) is a natural alkaloid with versatile bioactivities against several diseases including cancer and bacterial infection. EPI can induce the formation of a unique binding pocket at the 5' side of a human telomeric G-quadruplex (HTG) sequence with four telomeric repeats (Q4), resulting in a nanomolar binding affinity ( approximately 26 nM) with significant fluorescence enhancement upon binding. It is important to understand (1) how EPI binding affects HTG structural stability and (2) how enhanced EPI binding may be achieved through the engineering of the DNA binding pocket.

Validation of the Maslach Burnout Inventory-General Survey 9-item short version: psychometric properties and measurement invariance across age, gender, and continent.

Background: The Maslach Burnout Inventory-General Survey (MBI-GS) stands as the preeminent tool for assessing burnout across various professions. Although the MBI-GS9 emerged as a derivative of the MBI-GS and has seen extensive use over several years, a comprehensive examination of its psychometric properties has yet to be undertaken.

Methods: This study followed the Standards for Educational and Psychological Testing guidelines to validate the MBI-GS9.

High-Temperature Resistance of Anchorage System for Carbon Fiber-Reinforced Polymer Composite Cable-A Review.

Unidirectional carbon fiber-reinforced polymer (CFRP) may exhibit significant mechanical softening in the transverse direction at an elevated temperature. While significant transverse compressive stress exists on CFRP due to the clamping force from anchorage, a CFRP cable may exhibit anchorage failure when suffering an accidental fire disaster. The high-temperature resistance of a CFRP cable anchorage is critical, and clarifying the performance deterioration and failure mechanism of a CFRP cable anchorage system at elevated temperature is fundamental for clarifying its fire resistance.

Adsorption behavior and mechanism of Cu(II) by sodium alginate/carboxymethylcellulose/magnesium hydroxide (SC-MH) hydrogel.

In the present work, an environmentally-friendly, reusable hydrogel ball characterized by its great adsorption capacity to Cu(II) was synthesized. The preparation of this hydrogel drew on sodium alginate (SA) and carboxymethyl cellulose (CMC) as primary composition elements. The endeavor brought novelty by ingeniously infusing it with slurry magnesium hydroxide (MH).

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis.

Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.

Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up.

Background: Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare different age categories.

Methods: This retrospective cohort study recruited 102 GTS patients who underwent DBS between October 2006 and April 2022 at two national centers.

NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy.

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer.

An 8-week community-based resilience group intervention for Chinese parents who lost their only child: A two-armed pragmatic waitlist-control trial.

Objective: This study developed and evaluated a structured, 8-week community-based resilience group intervention for Chinese parents who have lost their only child and exhibit extended bereavement and suboptimal levels of resilience.

Method: Eighty parents were recruited from two communities and allocated to the intervention group ( = 42) or the waitlist-control group ( = 38). The 8-week community-based resilience group intervention was developed based on Kumpfer's resilience theory and previous studies.