Quality of life in children with chronic kidney disease-patient and caregiver assessments.

Background: Children with chronic kidney disease (CKD) require strict dietary and lifestyle modifications, however, there is little information on their quality of life. Our objective was to compare health-related quality of life (HRQOL) in children with different stages of CKD to each other and to a control population.

Methods: A cross-sectional assessment of HRQOL for physical, emotional, social and school domains was performed using the PedsQL Generic Core Scale.

The use of darbepoetin in infants with chronic renal impairment.

Darbepoetin is a newer analogue of epoetin, with a longer half-life, that allows less frequent administration. There are currently no published data available for its use in infants. We report our experience with this drug in infants with chronic renal impairment, weighing less than 8 kg.

Darbepoetin alfa (Aranesp) in children with chronic renal failure.

Background: Darbepoetin alfa use has been reported in 7 children with chronic renal failure (CRF). Our objective was to evaluate the efficacy and safety of darbepoetin and determine a therapeutic dose in a larger sample of children with CRF.

Methods: Twenty-six children with chronic renal insufficiency (CRI) GFR <30 mL/min/1.