Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing.

Objective: To study the role of α4β7 integrin for gut homing of monocytes and to explore the biological consequences of therapeutic α4β7 inhibition with regard to intestinal wound healing.

Design: We studied the expression of homing markers on monocyte subsets in the peripheral blood and on macrophage subsets in the gut of patients with IBD and controls with flow cytometry and immunohistochemistry. Integrin function was addressed with dynamic adhesion assays and in vivo gut homing assays.

An optical flow-based method to predict infantile cerebral palsy.

Cerebral palsy (CP) is a perinatally acquired nonprogressive brain damage resulting in motor impairment affecting mobility and posture. Early identification of infants with CP is desired to target early interventions and follow-up. During early infancy, distinct motion patterns occur which are highly predictive for later disability.