Publications by authors named "Annette J M Geerards"
Article Synopsis
- High myopia is increasingly common globally, leading to a rise in vision-related issues; however, research on its complications in Europeans is limited.
- The study aimed to evaluate the prevalence of myopic macular features among Europeans with high myopia, involving 626 patients from the Dutch Myopia Study and the Rotterdam Study.
- Results showed that 25.9% had myopic macular degeneration, which was more prevalent in older individuals, those with lower spherical equivalent refractive errors, and greater axial length.
Article Synopsis
- The study investigates the impact of the GJD2 gene on myopia (nearsightedness) across different age groups, looking specifically at its relationship with refractive error and eye measurements.
- Using data from three major population studies, researchers measured various eye metrics (like spherical equivalent and axial length) in relation to different GJD2 genotypes and assessed lifestyle factors' effects.
- Results showed that individuals with two risk alleles had worse eye measurements, indicating a dose-response effect that begins in early childhood, suggesting that this gene could significantly influence the development of myopia.
Article Synopsis
- * A large-scale study involving nearly 4,700 keratoconus cases and over 116,000 controls identified 36 genomic regions linked to the disease, highlighting issues with collagen integrity and cell differentiation as crucial factors.
- * The findings reveal shared genetic mechanisms with other corneal diseases and suggest that the identified genetic variants account for 12.5% of keratoconus's genetic risk, paving the way for future diagnostic tests to assess susceptibility.
Importance: Myopia (ie, nearsightedness) is becoming the most common eye disorder to cause blindness in younger persons in many parts of the world. Visual impairment due to myopia is associated with structural changes of the retina and the globe because of elongation of the eye axis. How axial length-a sum of the anterior chamber depth, lens thickness, and vitreous chamber depth-and myopia relate to the development of visual impairment over time is unknown.
View Article and Find Full Text PDFPurpose: To investigate the clinical presentation, isolated organism, treatment, and morbidity of contact lens-associated microbial keratitis needing hospitalization.
Methods: This retrospective study included all consecutive patients with contact lens-associated microbial keratitis hospitalized in the Rotterdam Eye Hospital from January 1, 2005, to December 31, 2009. All data regarding epidemiological characteristics, clinical presentation, isolated organism, and treatment were collected from medical records.
Purpose: To investigate the long-term effect of oral acyclovir administered during the first 6 months after penetrating keratoplasty (PK) for herpetic eye disease (HED).
Methods: A 5-year follow-up was undertaken for a patient population from a placebo-controlled, randomized trial on acyclovir prophylaxis after keratoplasty. In this former study the effectiveness of oral acyclovir prophylaxis was significant during the first 2 years after keratoplasty.
Purpose: To review retrospectively the charts of all 190 patients who underwent penetrating keratoplasty for keratoconus in one hospital during a 5-year period (1995-2000), with special attention paid to contact lens fitting.
Methods: The frequency of postoperative contact lens use, the time to fit lenses after grafting, tolerance and visual acuity, and postoperative risks for the graft were studied.
Results: The authors successfully fitted large-diameter (12 mm) tricurve rigid gas-permeable contact lenses for 90 (47%) of 190 penetrating keratoplasty patients with good tolerance.
Purpose: The purpose of this study is to evaluate corneal astigmatism and suture-related complications for transplants sutured with nylon and transplants sutured with Mersilene in primary corneal transplants for Fuchs endothelial dystrophy.
Methods: A retrospective, observational, and comparative study between transplants sutured with either nylon 10-0 or 11-0 (n = 108) or Mersilene 11-0 (n = 58) was done. One hundred sixty-six eyes of 140 patients who received a primary penetrating keratoplasty for Fuchs endothelial dystrophy between 1995 and 2001 at the Rotterdam Eye Hospital in Netherlands were included.
Recovery of the visual acuity in a family with Reis-Bückler dystrophy.
Cont Lens Anterior Eye
June 2002
Background: The hereditary Reis-Bückler dystrophy is one of the anterior localised corneal dystrophies with superficial reticulated opacities, sometimes in combination with recurrent attacks of corneal erosion. Phototherapeutic keratectomy (PTK) is now the first method to consider for managing this disease when intervention is required.
Methods: We treated six eyes of four related patients with Reis-Bückler dystrophy, who had a demonstrable reduction in visual acuity due to corneal opacities within their virgin corneas (three eyes), penetrating (one eye) or lamellar (two eyes) grafts.
Objective: To determine the prophylactic effect of oral acyclovir on the recurrence rate of herpetic eye disease after penetrating keratoplasty.
Design: A randomized, double-masked, placebo-controlled multicenter trial.
Participants: Sixty-eight consecutive patients (68 eyes) with corneal opacities due to herpetic eye disease who underwent penetrating keratoplasty.
Objectives: To describe the refractive results of cataract surgery after photorefractive keratectomy (PRK) for patients with myopia, and to find a more accurate method to predict intraocular lens (IOL) power in these cases.
Design: Nonrandomized, retrospective clinical study.
Patients And Methods: Nine patients (15 eyes) who underwent cataract surgery after prior PRK to correct myopia were identified.