Publications by authors named "Annette Dumas"
Article Synopsis
- - Alzheimer's disease (AD) is a widespread and progressive form of dementia, impacting nearly 7 million individuals in the EU and leading to severe memory loss and loss of independence.
- - Current healthcare practices for detecting and diagnosing AD focus mainly on the late stages of the disease, despite advancements in understanding its progression, resulting in ineffective treatment and diagnosis.
- - The European Brain Council's White Paper emphasizes the need to improve healthcare systems for early diagnosis by overcoming barriers and fully utilizing tools like biomarkers, PET scans, and CSF tests, which are currently under-used.
The climate change has the potential to dramatically affect species' thermal physiology and may change the ecology and evolution of species' lineages. In this work, we investigated the transition of dynamics in the heat shock response when the thermal stress approaches the upper thermal limits of species to understand how the climate change may affect the heat shock responses in ectotherms and endotherms. The heat shock protein 70, HSP70, prevents protein denaturation or misfolding under thermal stresses.
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- The MOPEAD project aims to improve the detection and diagnosis of Alzheimer's disease (AD) through various patient-engagement strategies across five European countries.
- Four screening methods were tested: a web approach, Open-House initiatives, screenings in primary care, and by diabetes specialists, with results showing different costs per true-positive (TP) diagnosis for each method.
- Primary care and diabetes specialists were the most cost-effective methods for diagnosing AD, but their ability to identify at-risk patients effectively raises questions, suggesting a potential need for refined web and Open-House strategies.
Article Synopsis
- General practitioners (GPs) are crucial for early dementia detection, but often fail to diagnose it on time, prompting a study on their attitudes and barriers in five European countries.
- Out of 343 GPs surveyed, 74% believe early diagnosis is important, but opinions vary by country regarding reimbursement and consultation time for patients.
- If an effective drug for slowing Alzheimer’s progression were available, 59% of GPs indicated they would change how they approach early diagnosis, highlighting the impact of treatment options on diagnostic practices.
Article Synopsis
- Dementia, particularly Alzheimer's disease, is often diagnosed too late, missing the benefits of early detection for patients and society.
- A new initiative, the Models of Patient Engagement for Alzheimer's Disease project, aims to improve early diagnosis by comparing four innovative patient engagement strategies across five European countries.
- Strategies include an online citizen science platform, open house events at memory clinics, and engagement methods in primary care and diabetes clinics to identify individuals with early stages of Alzheimer's typically overlooked.