Design and prospective validation of a dosing instrument for continuous infusion of vancomycin: a within-population approach.

Introduction: The clinical application of continuous infusion (CoI) of vancomycin has gained interest in recent years. Since no international guidelines on initial dosing of vancomycin CoI exist, there is a need for methods to facilitate the switch from intermittent to continuous vancomycin dosing algorithms in clinically infected populations. Therefore, the aim of this study was to design and validate an a priori dosing schedule for CoI of vancomycin in clinical practice.

[Continuous and intermittent infusion of vancomycin equally effective: review of the literature].

Objective: To compare the efficacy of continuous vancomycin infusion with intermittent vancomycin infusion based on clinical endpoints.

Design: Systematic review of the literature.

Method: Sixty articles on comparative studies on continuous and intermittent vancomycin infusion were found in Pubmed.