Publications by authors named "Annemiek C C Evers"
Background: Von Willebrand disease (VWD) type 3 is characterized by a complete deficiency of von Willebrand factor (VWF), resulting in a severe bleeding phenotype. Treatment often requires administration of VWF concentrates/factor (F)VIII. However, the development of alloantibodies is a rare complication, resulting in ineffective recovery and allergic reactions.
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- Severe postpartum hemorrhage (SPPH) is a significant cause of maternal death worldwide, and the study aimed to investigate how platelet abnormalities during pregnancy relate to SPPH.
- Data from over 23,000 deliveries were analyzed, revealing that women with low platelet counts (thrombocytopenia) had a higher risk of developing SPPH, especially those with very low counts (<50 × 10 /L).
- The research concludes that while different levels of low platelet counts are linked to SPPH occurrences, factors like plateletcrit and high platelet distribution width have limited additional importance beyond platelet count alone.