Publications by authors named "Annemarie Behmel"
Hereditary and sporadic medullary thyroid carcinoma (MTC) are closely associated with RET proto-oncogene mutations. However, the role of additional changes in the tumor genomes remains unclear. Our objective was the identification of chromosomal regions involved in MTC tumorigenesis and to assess their significance by using MTC-derived cell lines.
View Article and Find Full Text PDFArticle Synopsis
- Carcinoids are rare tumors that arise from specific cells in the body and have a growing incidence, with surgery being the only effective treatment option.
- Research has focused on growing human neuroendocrine tumor (NET) cell lines due to the challenges associated with obtaining enough tissue and the low growth rates of carcinoid cells.
- The study successfully established three new tumor cell lines from a metastatic human carcinoid, which maintain neuroendocrine properties and may serve as valuable models for future therapy development.
A unilateral, apparently sporadic pheochromocytoma was removed from the right adrenal of a 73-yr-old Caucasian woman. At the time of surgery, germline DNA from the patient was not available. However, a continuous cell line (KNA) established from the tumor showed a heterozygous sequence variant TGC (cysteine) to TGG (tryptophan) in exon 10, codon 611 of the RET proto-oncogene.
View Article and Find Full Text PDF