Publications by authors named "Annelli SandbAEk"

Background: Video consultations (VC) disrupt how general practice provides care and how patients receive it. A step towards understanding the use of VC is to study the association between user-status and general practitioner and practice characteristics.

Aim: To study the association between general practitioner and general practice characteristics and VC user-status (users, never users, and former users).

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Aims: Type 2 diabetes is linked to psychological distress and a doubled risk of depression. This study aims to characterize individuals with type 2 diabetes experiencing diabetes distress and/or depression in relation to lifestyle and metabolic outcomes.

Methods: A population-based survey in 2020 targeted individuals with type 2 diabetes (aged 18-75 years) in the Central Denmark Region.

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Aim: The aim of this study is to estimate the causally attributable one-year healthcare costs for individuals getting a type 2 diabetes diagnosis compared to a matched sample and show the incurred costs of medication and in primary and secondary healthcare.

Methods: Causal estimation using a difference-in-differences design to estimate the one-year health care costs attributable to type 2 diabetes. Danish registry data consisting of the entire population in years 2016-2019.

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Article Synopsis
  • Despite improvements in preventing cardiovascular issues, people with diabetes in Denmark still face higher death rates, particularly from cancer.
  • An analysis of data from 2002 to 2019 showed that while heart-related deaths decreased, cancer became the primary cause of death, especially in those with type 2 diabetes (T2D).
  • The study highlights the urgent need for diabetes care strategies that include cancer prevention efforts, with particular attention to the increased mortality risk observed in women with diabetes compared to men.
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In early 2023, a new type of weight loss medication, Wegovy (semaglutide), was made available in Denmark. Both subsequent media coverage and public demand were huge. Wegovy is only available by prescription, primarily via general practitioners.

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Background: Healthcare systems face escalating capacity challenges and patients with repeated acute admissions strain hospital resources disproportionately. However, studies investigating the characteristics of such patients across all public healthcare providers in a universal healthcare system are lacking.

Objective: To investigate characteristics of patients with repeated acute admissions (three or more acute admissions within a calendar year) in regard to sociodemographic characteristics, disease burden, and contact with the primary healthcare sector.

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Article Synopsis
  • * Data from 178 participants with type 2 diabetes and 32 healthy controls were analyzed, revealing that NfL levels were significantly higher in those with DPN compared to those without.
  • * While NfL may not be a dependable indicator for the presence of DPN, it is associated with the severity of nerve damage related to the condition.
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Physical activity and exercise therapy appear safe and beneficial for people with multimorbidity and should therefore be considered in the prevention and management of multimorbidity, as argued in this review. General practitioners and specialists should refer people with multimorbidity to supervised exercise therapy (2-3 times/week for 8-12 weeks, strengthening or aerobic exercise or a combination), while encouraging and educating patients to improve physical activity to improve overall health by e.g.

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The prevalence of type 2 diabetes (T2D) is higher in migrants compared to native populations in many countries, but the evidence on disparities in T2D care in migrants is inconsistent. Therefore, this study aimed to examine this in Denmark. In a cross-sectional, register-based study on 254,097 individuals with T2D, 11 indicators of guideline-level care were analysed: a) monitoring: hemoglobin-A1c (HbA1c), low-density lipoprotein cholesterol (LDL-C), screening for diabetic nephropathy, retinopathy, and foot disease, b) biomarker control: HbA1c and LDL-C levels, and c) pharmacological treatment: glucose-lowering drugs (GLD), lipid-lowering drugs, angiotensin-converting enzyme-inhibitors/angiotensin receptor blockers, and antiplatelet therapy.

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Background: Primary care providers see patients with obesity in general practice every day but may be challenged regarding communication about obesity. The research question of this study is: how do general practitioners and general practice staff and adult patients with obesity communicate about weight-related issues?

Methods: A scoping review approach was used, searching PubMed, Scopus and CINAHL for peer-reviewed studies - of both quantitative and/or qualitative study designs, and published between 2001 and 2021.

Results: Twenty articles were included.

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Aim: To examine disparities in glucose-lowering drug (GLD) usage between migrants and native Danes with type 2 diabetes (T2D).

Materials And Methods: In a nationwide, register-based cross-sectional study of 253 364 individuals with prevalent T2D on December 31, 2018, we examined user prevalence during 2019 of (i) GLD combination therapies and (ii) individual GLD types. Migrants were grouped by origin (Middle East, Europe, Turkey, Former Yugoslavia, Pakistan, Sri Lanka, Somalia, Vietnam), and relative risk (RR) versus native Danes was computed using robust Poisson regression to adjust for clinical and socioeconomic characteristics.

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Aims: This study aimed to examine the association between type 2 diabetes and poor self-rated oral health, and to investigate whether such association is modified by socioeconomic position.

Methods: We conducted a cross-sectional study, including a population aged 18-75 years with self-reported type 2 diabetes (N = 41,884) and a sex-, age- and municipality-matched reference population from the Health in Central Denmark survey (2020). Multivariable logistic regression was used, and effect modification of indicators of socioeconomic position was examined.

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Article Synopsis
  • Sleep duration shows a negative relationship with obesity measures such as BMI and waist circumference, indicating that less sleep is linked to higher obesity levels.
  • In a study of 1,309 older Danish adults, stronger associations were found after adjusting for variables, although the visceral-to-subcutaneous fat ratio did not show significant changes.
  • The findings suggest a clear connection between short sleep duration and increased obesity but highlight the need for more research to understand potential health benefits of improving sleep patterns.
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Purpose: To validate two register-based algorithms classifying type 1 (T1D) and type 2 diabetes (T2D) in a general population using Danish register data.

Patients And Methods: After linking data on prescription drug usage, hospital diagnoses, laboratory results and diabetes-specific healthcare services from nationwide healthcare registers, diabetes type was defined for all individuals in Central Denmark Region age 18-74 years on 31 December 2018 according to two distinct register-based classifiers: 1) a novel register-based diabetes classifier incorporating diagnostic hemoglobin-A1C measurements, the (OSDC), and 2) an existing Danish diabetes classifier, the (RSCD). These classifications were validated against self-reported data from the survey - overall and stratified by age at onset of diabetes.

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Article Synopsis
  • - PAPP-A, an enzyme involved in breaking down IGF-binding proteins, has been linked to an increased risk of cardiovascular disease (CVD) and higher all-cause mortality in patients with type 2 diabetes (T2D), specifically in a study of 1284 participants over 5 years.
  • - The study found that higher levels of STC2 and PAPP-A, as well as IGFBP4, correlate with increased mortality rates, while lower levels of IGF1 are associated with higher mortality.
  • - The findings suggest that while PAPP-A contributes to CVD risk and mortality, STC2 might act as a counterbalance to its harmful effects or have independent impacts beyond the PAPP-A-
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Background: To support the primary care sector in delivering high-quality type 2 diabetes (T2D), literature reviews emphasize the need for implementing models of collaboration that in a simple and effective way facilitate clinical dialogue between general practitioners (GPs) and endocrinologists. The overall aim of the project is to evaluate if virtual specialist conferences between GPs and endocrinologists about patients living with T2D is clinically effective and improves diabetes competences and organization in general practice in comparison to usual practice.

Methods: A prospective, pragmatic, and superiority RCT with two parallel arms of general practices in the Municipality of Aarhus, Denmark.

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Background: We aimed to examine the impact of gender and specific type of cardiovascular disease (CVD) diagnosis (ischemic heart disease [IHD], heart failure, peripheral artery disease [PAD] or stroke) on time-to-initiation of either a sodium glucose cotransporter 2 inhibitor or glucagon-like peptide 1 analogue (collectively termed cardioprotective GLD) after a dual diagnosis of type 2 diabetes (T2DM) and CVD.

Methods: In a nationwide cohort study, we identified patients with a new dual diagnosis of T2DM and CVD (January 1, 2012 and December 31, 2018). Cumulative user proportion (CUP) were assessed.

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This review focuses on communication about weight-related issues with patients with obesity in general practice. Primary care providers still lack knowledge and tools to address and communicate about the topic of weight and weight-related issues - with focus on minimizing stigmatization and a person centered approach. A few communication tools on the topic have been developed but it seems that the use of those is limited, suggesting an urgent need for making a fast, easy and simple tool for the use in general practice.

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Background: During the COVID-19 pandemic, video consultations became a common method of delivering care in general practice. To date, research has mostly studied acute or subacute care, thereby leaving a knowledge gap regarding the potential of using video consultations to manage chronic diseases.

Objective: This study aimed to examine general practitioners' technology acceptance of video consultations for the purpose of managing type 2 diabetes in general practice.

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Purpose: The Health in Central Denmark (HICD) cohort is a newly established cohort built on extensive questionnaire data linked with laboratory data and Danish national health and administrative registries. The aim is to establish an extensive resource for (1) gaining knowledge on patient-related topics and experiences that are not measured objectively at clinical health examinations and (2) long-term follow-up studies of inequality in diabetes and diabetes-related complications.

Participants: A total of 1.

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Objective: To explore health-care use in the 12 months preceding a diagnosis of RA in Denmark.

Methods: We conducted a population-based cohort study using data from national registries. Every patient diagnosed with RA in 2014-18 was matched to 10 reference individuals without RA from the Danish background population.

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Background: Little is known about variations in the provision of chronic care services in primary care.

Aim: To describe the frequency of chronic care services provided by GPs and analyse the extent of non-random variation in service provision.

Design And Setting: Nationwide cohort study undertaken in Denmark using data from 2016.

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Background: Depression is highly prevalent among hospitalized patients with pneumonia. At discharge, these patients transfer to a less care-intensive home-based setting. Nevertheless, little is known on the prognosis in the postdischarge period.

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Objectives: Potentially inappropriate medications (PIMs) pose an increasing challenge in the ageing population. We aimed to assess the extent of PIMs and the prescriber-related variation in PIM prevalence.

Design: Nationwide register-based cohort study.

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Background: Health checks have been suggested as an early detection approach aiming at lowering the risk of chronic disease development. This study aimed to evaluate the effectiveness of a health check programme offered to the general population, aged 30-49 years.

Methods: The entire population aged 30-49 years (N=26 216) living in the municipality of Randers, Denmark, was invited to a health check during 5 years.

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