Imaging flow cytometry as a novel approach for the diagnosis of heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is an adverse reaction characterized by anti-PF4-heparin antibody generation and hypercoagulability. Imaging flow cytometry (IFC) provides a detailed morphological analysis of platelets, which change upon activation. We evaluated IFC-derived morphometric features to detect platelet activation and developed a functional assay for HIT diagnosis.

Quality evaluation of the management of oral anticoagulation therapy (OAT): the awareness of treating physicians and the education of patients needs to be improved.

The adverse effects of oral anticoagulant therapy (OAT) are the main cause of hospitalization for drug accidents, and most of them could be avoided by more rigorous management. We conducted a prospective study based on the analysis of individuals under OAT recruited among the patients admitted to our hospital. The aim was to evaluate the legitimacy of OAT and the quality of its management by referring to general recommendations.

[Assessment of the quality of oral anticoagulation management in patients admitted to Amiens University Hospital].

Background: Excessive or insufficient anticoagulation therapy and its associated risks are of major concern in patients receiving oral anticoagulants. Such complications can be avoided by more rigorous management.

Objective: The aim of our study was to evaluate those patients receiving oral anticoagulant therapy on the day of hospitalisation among all patients admitted to the Amiens University Hospital during 14 days.