Publications by authors named "Annelie Maskell"
Aims: To develop a position statement that identifies research priorities in diabetic kidney disease and provides recommendations to researchers and research funders on how best to address them.
Methods: A one-day research workshop was conducted, bringing together research experts in diabetes and kidney disease, healthcare professionals, and people living with diabetes, to identify and prioritise research recommendations.
Results: The following key areas were identified as needing increased focus: Understanding causal mechanisms in diabetic kidney disease Prevention of diabetic kidney disease Addressing health inequalities Improving diagnosis Improving care Supporting self-management CONCLUSIONS: This position statement outlines recommendations to address the urgent need to tackle diabetic kidney disease and calls on the diabetes and kidney research communities to act upon these recommendations to ensure future research works to eliminate unfair and avoidable disparities in health.
Article Synopsis
- New treatment options are needed for high-grade serous carcinoma (HGSC), as it often spreads to the omentum and promotes tumor growth through angiogenesis.
- Researchers investigated how cathepsin L (CathL) from HGSC affects the production of galectin-1 (Gal1) in human omental microvascular endothelial cells (HOMECs), which may play a role in tumor development.
- The study found that CathL increases Gal1 synthesis, enhancing cell migration and proliferation in an autocrine manner, suggesting that targeting Gal1 could offer a new therapeutic approach in treating metastasized HGSC.