Publications by authors named "Annelie Cuvenhaus"
Purinergic Signal
June 2020
Article Synopsis
- The alveolar epithelium plays a crucial role in gas exchange and serves as an immune barrier, releasing cytokines and surfactant to maintain lung health.
- Extracellular ATP from alveolar epithelial cells activates purine receptors (P2Rs) and is essential for lung function, but preparing primary isolated type II alveolar epithelial cells (piAECs) is complicated and involves animal sacrifice.
- This study analyzed the expression and functionality of P2Rs in piAECs compared to immortalized and tumor-derived AEC lines, revealing that while all cell lines expressed P2Y and P2X, only L2 and piAECs showed functional P2XR activity.
