Publications by Annelie Aguessi

Publications by authors named "Annelie Aguessi"

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Discovery of antichagasic inhibitors by high-throughput screening with Trypanosoma cruzi glucokinase.

Gustavo F Mercaldi Edward L D'Antonio Annelie Aguessi Ana Rodriguez Artur T Cordeiro

Bioorg Med Chem Lett

August 2019

A high-throughput screening (HTS) campaign was carried out for Trypanosoma cruzi glucokinase (TcGlcK), a potential drug-target of the pathogenic protozoan parasite. Glycolysis and the pentose phosphate pathway (PPP) are important metabolic pathways for T. cruzi and the inhibition of the glucose kinases (i.

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