Publications by authors named "Anne-Sophie Navionis"
Article Synopsis
- Inflammation plays a significant role in breast cancer progression and prognosis, particularly through pre-diagnostic plasma biomarkers in women.
- A study involving 1,538 women showed that elevated levels of the inflammatory marker IL-6 were linked to increased risks of all-cause and breast cancer-specific mortality, especially in postmenopausal women.
- Higher levels of IL-10 and TNFα were also associated with all-cause mortality, and an inflammatory score could indicate poorer long-term survival, particularly in postmenopausal breast cancer survivors.
Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank.
BMC Med
August 2024
Article Synopsis
- The study aimed to compare traditional and novel body shape indexes (like ABSI and HI) regarding their associations with inflammation markers, particularly C-reactive protein (CRP), using data from the EPIC and UK Biobank cohorts.
- Participants included nearly 444,000 individuals, with the analysis involving various body shape phenotypes derived from measurements such as height and weight.
- Results indicated that traditional measures like BMI and waist circumference were positively linked to CRP levels, while some body phenotypes showed varying associations by sex, highlighting the complexity of body shape and inflammation relationships.
Article Synopsis
- Obesity is linked to gastric cancer, with specific hormones playing a role in increasing the risk of both cardia gastric cancer (CGC) and non-cardia gastric cancer (NCGC).
- The study utilized data from multiple cohorts (EPIC, ATBC, and UK-Biobank) and assessed the relationship between obesity-related hormones and gastric cancer occurrence through various statistical methods.
- Key findings indicate that hormones like insulin-like growth-factor-1 and leptin are associated with increased risk, while ghrelin and dehydroepiandrosterone appear to have a protective effect against NCGC and CGC, respectively.
Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico.
Background: Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status.
Methods: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Background: Nutritional epidemiology research using self-reported dietary intake is prone to measurement error. Objective methods are being explored to overcome this limitation.
Objectives: We aimed to examine 1) the association between plasma markers related to inflammation and derive marker scores for dietary patterns [Mediterranean dietary score (MDS), energy-adjusted Dietary Inflammatory Index (E-DIITM), Alternative Healthy Eating Index 2010 (AHEI)] and 2) the associations of these marker scores with mortality.
Article Synopsis
- The study examined the relationship between 34 blood markers related to inflammation and aging, finding that most markers were associated with both age and mortality in participants aged 59 to 70.
- A specific "inflammaging" signature was developed, consisting of 10 key markers, which showed a strong correlation with increased mortality risk.
- The findings underscore the significant roles of the kynurenine pathway and vitamin B6 metabolism in the aging process and their potential impact on health outcomes.
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC.
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