CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients.

Background: Neuroblastoma is thought to originate from neural crest-derived cells. CD57 defines migratory neural crest cells in normal development and is expressed in neuroblastoma.

Methodology And Principal Findings: We investigated the role of CD57 expression in neuroblastoma cells ex situ and in situ.