Risk factors and characteristics of respiratory and allergic phenotypes in early childhood.

Background: Unsupervised approaches can be used to analyze complex respiratory and allergic disorders.

Objective: We investigated the respiratory and allergic phenotypes of children followed in the Pollution and Asthma Risk: An Infant Study (PARIS) birth cohort.

Methods: Information on respiratory and allergic disorders, medical visits, and medications was collected during medical examinations of children at 18 months of age; biomarker data were also collected (total and allergen-specific IgE levels and eosinophilia).

Can early household exposure influence the development of rhinitis symptoms in infancy? Findings from the PARIS birth cohort.

Background: Allergic rhinitis (AR) has become the most prevalent chronic allergic disorder in childhood, and the role of environment has been questioned, particularly in early life.

Objective: To investigate the risk factors for rhinitis symptoms in infants included in the PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort.

Methods: Infants were invited to participate at age 18 months in a health examination conducted by a pediatrician.