Objective and subjective evaluation of endoscopic nasal surgery outcomes.

Background: Chronic rhinosinusitis (CRS) symptoms include nasal obstruction, rhinorrhea, and facial pain associated with rhinosinusitis disability. When resistance to medical treatment is associated with endonasal anomalies, endoscopic nasal surgery (ENS) can be proposed. However, objective and subjective assessment criteria regarding the evaluation of ENS outcomes remain unclear.

Cytomegalovirus colitis--a severe complication after standard chemotherapy.

We report on a case of cytomegalovirus (CMV) enterocolitis occurring in a 65-year-old patient after a first course of standard chemotherapy for a small cell lung carcinoma (SCLC). Colonic biopsies showed typical inclusion bodies, CMV IgM and IgG antibodies were found in the serum, and polymerase chain reaction for CMV-DNA was positive. Lymphopenia and diminished CD4 T-cell counts were observed.

Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods.

The technique of sentinel lymph node (SLN) dissection is a reliable predictor of metastatic disease in the lymphatic basin draining the primary melanoma. Reverse transcription-polymerase chain reaction (RT-PCR) is emerging as a highly sensitive technique to detect micrometastases in SLNs, but its specificity has been questioned. A prospective SLN study in melanoma patients was undertaken to compare in detail immunopathological versus molecular detection methods.

Endoscopic removal of a nasal septum chondrosarcoma.

We describe an alternative, endoscopical technique for the surgical removal of a rare chondrosarcoma on the nasal septum. The technique requires a resection of the whole tumour within margins in healthy osteocartilaginous nasal septum under endoscopic guidance and includes bilateral middle turbinectomy and ethmoidectomy. We present the case of a 57-year-old woman with a well-differentiated chondrosarcoma (Grade I) of the nasal septum.