Safe early switch to oral antibiotics in immunocompetent adults with intracranial bacterial suppurations: Retrospective of a 25-year experience in a tertiary care centre.

Background: Switching antibiotic therapy from intravenous to oral route (IVOS) has become the standard of care for many deep-seated infections. IVOS seems applicable to intracranial bacterial suppurations (ICBS) with a good safety profile but remains debated and has shown insufficient evidence to be recommended in the latest guidelines. We hypothesize that early IVOS is not associated with a poorer neurological prognosis.

Antimicrobial prophylaxis in noninstrumented spine surgery: a prospective study to determine efficacy and drawbacks.

Objective: The authors sought to evaluate the roles of perioperative antibiotic prophylaxis in noninstrumented spine surgery (NISS), both in postoperative infections and the impact on the selection of resistant bacteria. To the authors' knowledge, only one prospective study recommending preoperative intravenous (IV) antibiotics for prophylaxis has been published previously.

Methods: Two successive prospective IV antibiotic prophylaxis protocols were used: from 2011 to 2013 (group A: no prophylactic antibiotic) and from 2014 to 2016 (group B: prophylactic cefazolin).

Elderly age as a prognostic marker of 1-year poor outcome for subarachnoid hemorrhage patients through its interaction with admission hydrocephalus.

Background: An increasing number of elderly patients are treated for aneurysmal subarachnoid hemorrhage. Given that elderly age is associated with both poor outcome and an increased risk of hydrocephalus, we sought to investigate the interaction between age and hydrocephalus in outcome prediction.

Methods: We enrolled 933 consecutive patients treated for subarachnoid hemorrhage between 2002 and 2010 and followed them for 1 yr after intensive care unit discharge.

Morbidity of ventricular cerebrospinal fluid shunt surgery in adults: an 8-year study.

Background: Cerebrospinal fluid (CSF) shunt procedures have dramatically reduced the morbidity and mortality rates associated with hydrocephalus. However, despite improvements in materials, devices, and surgical techniques, shunt failure and complications remain common and may require multiple surgical procedures.

Objective: To evaluate CSF shunt complication incidence and factors that may be associated with increased shunt dysfunction and infection rates in adults.

Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis.

Objective: To evaluate incidence and risk factors of postoperative meningitis, with special emphasis on antibiotic prophylaxis, in a series of 6243 consecutive craniotomies.

Methods: Meningitis was individualized from a prospective surveillance database of surgical site infections after craniotomy. Ventriculitis related to external ventricular drainage or cerebrospinal fluid shunt were excluded.

Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis.

Objective: To evaluate incidence and risk factors of postoperative meningitis, with special emphasis on antibiotic prophylaxis, in a series of 6243 consecutive craniotomies.

Methods: Meningitis was individualized from a prospective surveillance database of surgical site infections after craniotomy. Ventriculitis related to external ventricular drainage or cerebrospinal fluid shunt were excluded.

Diagnostic and therapeutic management of nosocomial pneumonia in surgical patients: results of the Eole study.

Objective: To assess clinical, microbiological, and therapeutic features of nosocomial pneumonias in surgical patients.

Design: Prospective (October 1997 through May 1998), consecutive case series analysis of patients suspected of having pneumonia during the fortnight after a surgical procedure or trauma and receiving antibiotic therapy prescribed by the attending physician for this diagnosis.

Setting: A total of 230 study centers in teaching (n = 66) and nonteaching hospitals (n = 164) (surgical wards and intensive care units).