Publications by authors named "Anne-Marie Decker"
Background & Aims: Sustained weight loss is highly desirable in obesity. Although the role of incretins in the regulation of body weight is well known, macronutrient specific incretin response and the effects of weight loss on this response have not been investigated before. We aimed to examine GLP-1, GIP, ghrelin, insulin, and satiety response to meals with different macronutrient composition in overweight and obese subjects before and after weight loss.
View Article and Find Full Text PDFBackground/objectives: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially involved in long-term body weight regulation after dietary weight loss. Thus, we aimed to analyze the impact of the hepatokine Fetuin-B in the context of weight loss induced short- and long-term modulation of adipose insulin sensitivity.
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- * Researchers used advanced techniques to analyze blood and subcutaneous white adipose tissue (SAT) from participants, focusing on T cell populations and their relationship with insulin sensitivity.
- * Findings reveal that while weight loss from CR improved overall insulin sensitivity, it did not significantly change inflammatory markers in SAT, indicating lasting immune changes due to obesity.
Article Synopsis
- This study looked at how using electronic forms (eCRF) for collecting data in clinical trials might be faster than using paper forms (pCRF).
- The researchers tested this idea during a weight loss trial, involving patients and study nurses, and found that eCRF was indeed quicker, saving about 2.25 minutes per form.
- They also found that the time saved did not depend on the type of participant, how long the forms were, or the patients' ages.
Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans.
J Clin Endocrinol Metab
November 2016
Context: Recently a potential role of betatrophin was shown in the postprandial switch from lipid to glucose metabolism.
Objective: The objective of the study was to analyze whether obesity is associated with altered postprandial betatrophin response and whether this could be restored by weight loss. Design, Setting, Participants, and Intervention: Oral glucose load was performed in 12 lean individuals at baseline as well as in 20 obese subjects before and after a 12-week structured weight-loss program at an endocrinology research center.
Introduction: In weight loss trials, a considerable inter-individual variability in reduction of fat mass and changes of insulin resistance is observed, even under standardized study conditions. The underlying mechanisms are not well understood. Given the metabolic properties of the atrial natriuretic peptide (ANP) system, we hypothesized that ANP signaling might be involved in this phenomenon by changes of ANP secretion or receptor balance.
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