Simulated Microgravity Created Using a Random Positioning Machine Induces Changes in the Physiology of the Species Complex.

is a phytopathogenic fungus involved in human pathology and is present in space stations. It is essential to understand the effects of microgravity on the physiology of this fungus to determine the potential risks to the health of crew members and to propose the necessary countermeasures. This study aimed to determine changes in the physiological parameters of the species complex under simulated microgravity generated using a random positioning machine (RPM) and phenotypic approaches.

Mutations in the Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus .

Members of species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients. Despite the treatment recommendations, many strains show reduced sensitivity to voriconazole. The objective of this work was to investigate the potential relationship between azole susceptibility and mutations in CYP51 protein sequences.