Publications by authors named "Anne-Lise Delastic"
People living with HIV (PLWHIV) present an increased risk of adverse cardiovascular events. We aimed to assess whether antiretroviral therapy (ART) pharmacologically enhances platelet reactivity and platelet activation intensity, and explore the potential association with underlying inflammatory status. This was a cross-sectional cohort study carried out among PLWHIV on diverse ART regimens.
View Article and Find Full Text PDFIntroduction: Infections impose a significant burden on healthcare costs worldwide. We aimed to explore antibiotic- and hospital-related costs of infections needing admission in a tertiary university hospital in Greece.
Methods: We performed a prospective cohort study in the medical care unit of a tertiary university hospital in Greece, for the period May 2016 to May 2018.
The presence of a complex immune dysregulation syndrome has been established in COVID-19 patients. We aimed to assess Th1/Th2 response in COVID-19 patients and its association with disease severity by performing a prospective cohort study in a tertiary hospital COVID-19 referral center. We report no difference between Th1/Th2 responses between patients with severe and mild disease, except for levels of interleukin-6 (IL-6) and IL-10.
View Article and Find Full Text PDFArticle Synopsis
- Prompt empiric antibiotic therapy (EAT) is crucial for treating infections, but many blood cultures don’t identify the pathogens, prompting a study on EAT patterns, outcomes, and costs in a university hospital.
- An analysis of 489 patients showed that intra-abdominal infections were most common, with a 67% success rate for EAT, while factors like urinary tract infections reduced failure chances, and sepsis increased them significantly.
- Patients with EAT failure faced longer hospital stays, higher antibiotic usage, and increased hospitalization costs, emphasizing the financial impact of unsuccessful treatments.