Optimization of temporal sampling for F-choline uptake quantification in prostate cancer assessment.

Background: Suboptimal temporal sampling of time-activity curves (TAC) from dynamic F-fluoromethylcholine (FCH) PET images may introduce bias in quantification of FCH uptake in prostate cancer assessment. We sought to define an optimal temporal sampling protocol for dynamic FCH PET imaging. Seven different time samplings were tested: 5 × 60″, 10 × 30″, 15 × 15″-1 × 75″, 6 × 10″-8 × 30″, 12 × 5″-8 × 30″; 10 × 5″-4 × 10″-3 × 20″-5 × 30″, and 8 × 3″-8 × 12″-6 × 30″.

Comparison of choline influx from dynamic F-Choline PET/CT and clinicopathological parameters in prostate cancer initial assessment.

Aim: The aim of the study was to compare the kinetic analysis of F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC).

Materials And Methods: Sixty-one patients were included. PSA was performed few days before FCH PET/CT.