In recent decades, there has been a notable increase in antibiotic-resistant isolates, necessitating the development of innovative treatments to combat this pathogen. This manuscript explores the potential of different phage proteins to attenuate virulence factors of , particularly the type II secretion system (T2SS). PIT2, a protein derived from the lytic phage LMA2 inhibits the T2SS effectors PrpL and LasA and attenuates the bacterial virulence toward HeLa cells and .
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