Publications by authors named "Anne-Laure Ejeil"
Background: The study aimed to examine the prevalence of gingival cancers compared to other oral mucosal sites, analyze patient profiles, and identify risk factors.
Materials And Methods: A retrospective monocentric study was conducted at the Department of Oral Medicine of Bretonneau Hospital in Paris, France. 32 patients diagnosed with oral mucosal cancer were included.
Article Synopsis
- The study aims to determine the best oral biopsy site for diagnosing mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV) by comparing clinical data with direct immunofluorescence (DIF) results.
- A systematic review of 16 studies found that gingival biopsies provided a 100% rate of DIF contribution for PV, while rates were 90.2% for MMP, with significant variability among other oral biopsy sites.
- The findings suggest that the choice of biopsy location should prioritize the clinical presentation and the healthy areas near active lesions rather than impact on DIF rates, emphasizing the importance of balancing the benefits and risks of the biopsy procedure.
Ewing's Sarcoma of Mandible: A Case Report with Review of Literature.
Int J Clin Pediatr Dent
February 2024
Background: Ewing sarcoma (ES), a rare malignancy, comprises whatever the age, 4-15% of all primary bone tumors. It represents 1% of all malignant tumors in children and is the fourth most common bone malignancy after myeloma, osteosarcoma, and chondrosarcoma.
Case Description: A 12-year-old boy came to the Oral Surgery Department of Bretonneau Hospital referred by his dentist with a rapidly evolving swelling in the left mandibula for 6 weeks, which was initially diagnosed as a facial cellulitis.
Article Synopsis
- Mucous membrane pemphigoid with gingival expression (gMMP) leads to ongoing gingival pain, causing poor oral comfort and difficulty in achieving complete healing despite medical treatment.* -
- A study of 15 gMMP patients found three dominant communities of harmful bacteria in their subgingival biofilm, regardless of their treatment status, suggesting a dysbiotic microbiota is present.* -
- There is a significant link between the duration of gMMP and the severity of gingivitis and periodontal tissue loss, highlighting the need for combined medical and periodontal therapy, with further studies needed for validation.*
Article Synopsis
- During the first wave of COVID-19 in France, dentists were deemed high-risk for infection, leading to a lockdown where they could only address emergencies, which helped control virus spread.
- A survey of nearly 3,500 French dentists revealed a 3.6% COVID-19 prevalence, with findings showing that wearing surgical masks in non-aerosol procedures increased risk, while limiting patient numbers was protective.
- The study concluded that when proper protective measures are taken, dentists are not at greater risk of COVID-19 than the general public, suggesting the need for stronger PPE guidelines and patient management to mitigate virus spread.
Background: Chronic erosive gingivitis, also called desquamative gingivitis, defines a clinical picture that can be generated by several inflammatory and immune diseases. Pathology is therefore essential for the differential diagnosis. However, when the gingival lesion is initial, exclusive or predominant, selecting the biopsy site and protocol may be problematic due to tissue fragility.
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- A study was conducted in April 2020 involving French dental professionals to investigate the risk of contracting COVID-19 in the dental field, highlighting an increased risk for health-care workers and suggesting oral health-care professionals might be particularly vulnerable.
- The survey included responses from 4,172 dentists and 1,868 dental assistants, revealing a lab-confirmed COVID-19 prevalence of 1.9% for dentists and 0.8% for dental assistants, with some clinical phenotypes appearing in 15% or more of positive cases.
- The results indicated that factors like chronic kidney disease and obesity increased the odds of contracting COVID-19, while specific dental practices and changes in work routines could lower the risk, showing dental professionals were not
Background: Osseous dysplasia (OD) is the most common fibro-osseous lesion of the jaw affecting the periapical region. Early stages of OD can resemble periapical radiolucencies, thus mimicking the radiological aspects of an endodontic pathology. Such radiolucent lesions affecting previously decayed or treated teeth are even more complex to interpret.
View Article and Find Full Text PDFUnusual gingival swelling in a 4-year-old child.
Oral Surg Oral Med Oral Pathol Oral Radiol
December 2014
Article Synopsis
- This study investigates the effects of a vegetable extract from Lupinus albus (LU 105) on gingival fibroblasts, particularly how it influences the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs).
- The research involved culturing both healthy and inflamed gingival biopsies with LU 105, assessing changes in MMP and TIMP expression and the secretion of cytokines using various biochemical analyses.
- Results showed that LU 105 significantly reduced MMP and TIMP activity and altered cytokine levels, suggesting its potential as a clinical treatment with minimal impact on cell proliferation and morphology.
Background: Evidence of the role of cytokines produced by resident and inflammatory cells during inflammation is well established. The aim of this study was to quantify in healthy and diseased human gingiva the area fraction (AA%) occupied by collagen fibers and the amount of cytokines such as interleukin (IL)-1beta, IL-4, IL-6, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta, and epidermal growth factor (EGF) to investigate a possible correlation between such cytokines, collagen degradation, and the gingival index.
Methods: Gingival tissue specimens from 6 healthy controls (group 1), 6 patients with mild gingival inflammation (group 2), 6 patients with moderate gingival inflammation (group 3), and 6 patients with severe gingival inflammation (group 4) were cultured for 72 hours, and the cytokines present in the culture media were quantified using an enzyme-linked immunosorbent assay (ELISA).
Background: The purpose of this study was to quantify the amount of matrix metalloproteinases such as MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-13 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 expressed by human gingival explants in culture media and the area fraction (AA%) of gingival collagen fibers according to the degree of inflammation, to investigate a possible correlation between these enzymes and collagen loss.
Methods: Gingival tissue specimens from 6 healthy controls (group 1), 17 patients with mild gingival inflammation (group 2), 10 patients with moderate gingival inflammation (group 3), and 9 patients with severe gingival inflammation (group 4) were placed in organ culture for 3 days. The MMPs and TIMPs in the culture media were quantified using zymography, dot blotting, and Western blotting.