High-dose methotrexate prior to simultaneous radiochemotherapy in children with malignant high-grade gliomas.

Background: Preradiation chemotherapy including methotrexate (MTX) was effective in children with completely resected high-grade gliomas (HGG). The specific role of MTX remains uncertain.

Patients And Methods: Children with newly diagnosed HGG and diffuse intrinsic pontine gliomas (DIPG) were enrolled.