Prospective Acceptability of Digital Therapy for Major Depressive Disorder in France: Multicentric Real-Life Study.

Background: Major depressive disorder is one of the leading causes of disability worldwide. Although most international guidelines recommend psychological and psychosocial interventions as first-line treatment for mild to moderate depression, access remains limited in France due to the limited availability of trained clinicians, high costs for patients in the context of nonreimbursement, and the fear of stigmatization. Therefore, online blended psychological treatment such as Deprexis could improve access to care for people with depression.

Understanding the potential of digital therapies in implementing the standard of care for depression in Europe.

Depressive disorders represent the largest proportion of mental illnesses, and by 2030, they are expected to be the first cause of disability-adjusted life years [1]. The COVID-19 pandemic exacerbated prevalence and burden of depression and increased the occurrence of depressive symptoms in general population [2]. The urgency of implementing mental health services to address new barriers to care persuaded clinicians to use telemedicine to follow patients and stay in touch with them, and to explore digital therapeutics (DTx) as potential tools for clinical intervention [2].

Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients.

Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30-40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving.

[Clinical characteristics of obsessivecompulsive disorder].

Clinical characteristics of obsessive-compulsive disorder. Obsessive-compulsive disorders (OCD) are composed by repetitive behaviors and intrusive thought, associated with doubt and avoidance. Washers and checkers are the most common dimension of OCD, but it can also be characterized by taboo thoughts or other personalized symptoms.

[Classification of obsessivecompulsive disorder: evolution in the DSM-V].

Classification of obsessive-compulsive disorder : evolution in the DSM V. Obsessive-compulsive disorder (OCD) criteria were first described in the third edition of Diagnostic and statistical manual of mental disorders (DSM), in the 1980's. OCD was then classified as an anxious disorder.

Recent advances in deep brain stimulation in psychiatric disorders.

Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders.

Altered anatomical connections of associative and limbic cortico-basal-ganglia circuits in obsessive-compulsive disorder.

Background: Current neurocognitive models suppose dysfunctions of associative and limbic cortico-basal ganglia circuits to be at the core of obsessive-compulsive disorder (OCD). As little is known about the state of underlying anatomical connections, we investigated whether these connections were reduced and/or not properly organised in OCD patients compared to control.

Methods: Diffusion magnetic resonance images were obtained in 37 OCD patients with predominant checking symptoms and 37 matched healthy controls.

Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder.

Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that is dramatically exacerbated in obsessive-compulsive disorder. We recently showed that deep brain stimulation in the associative-limbic area of the subthalamic nucleus, a central core of the basal ganglia, improved obsessive-compulsive disorder. To understand the physiological bases of symptoms in such patients, we recorded the activity of individual neurons in the therapeutic target during surgery while subjects performed a cognitive task that gave them the possibility of unrestricted repetitive checking after they had made a choice.

Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder.

Background: The role of dopamine in reinforcement learning has been extensively studied, but the role of other major neuromodulators, particularly serotonin, remains poorly understood. An influential theory has suggested that dopamine and serotonin represent opponent systems respectively driving reward and punishment learning.

Methods: To test this theory, we compared two groups of patients with obsessive-compulsive disorder, one unmedicated (n = 12) and one treated with serotonin reuptake inhibitors (SRI; n = 13).