Publications by authors named "Anne-Claude Couffin-Hoarau"
Poly(L-lysine citramide) is a degradable bioresorbable polyanion whose polyamide chains are composed of citric acid and L-lysine building blocks. Its chemical and physicochemical properties were extensively investigated in the past for its interest as polymeric drug carrier. In this work, 4(S)-amino-3-(S)-hydroxy-5-phenylpentanoyl-isoleucyl-phenylalanine methyl ester, a pseudopeptide active against the HIV protease in vitro, was linked to poly(L-lysine citramide) in attempts to promote solubility and cell penetration.
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- Recent advances in biotechnologies have enabled the creation of therapeutic agents that require complicated formulations for effective delivery.
- The study introduces a new method for sustained, systemic delivery of these agents by using self-assembling amino acid derivatives mixed with a vegetable oil to form injectable organogels.
- Testing on rats showed that this gel could slowly release leuprolide over 14 to 25 days, effectively maintaining low testosterone levels for up to 50 days, providing a simpler alternative to existing delivery technologies.
Article Synopsis
- The research focuses on creating effective drug delivery systems for sustained release of peptides, proteins, and small hydrophilic molecules using biodegradable in situ-forming implants.
- Six new amphiphilic gelators derived from L-alanine were developed and were able to gel various oils suitable for injectable use, with their gelation properties influenced by their structure and concentration.
- Preliminary tests on rats showed that these organogels had a good biocompatibility profile, with only mild chronic inflammation observed, indicating their potential as a platform for sustained drug delivery.
A novel family of amphiphilic temperature- and pH-sensitive poly(organophosphazenes) with varying ratios of ethylene oxide, alkyl chains and free acid units was synthesized by living cationic polymerization. Depending on their composition, these poly(organophosphazenes) exhibited lower critical solution temperatures ranging from 32 to 44 degrees C, which were pH-dependent for copolymers bearing carboxylic acid groups. The alkylated copolymers were then anchored into phospholipid bilayers to obtain stimuli-responsive liposomes that released their content upon a change in temperature or pH.
View Article and Find Full Text PDFPurpose: To characterize novel pharmaceutical organogels based on the self-assembly of L-alanine derivatives in hydrophobic vehicles.
Methods: The gelation properties of N-lauroyl-L-alanine (LA) and N-lauroyl-L-alanine methyl ester (LAM) were investigated in the presence of various solvents. Gel-sol and sol-gel transitions were evaluated by the inverse flow method, and gelation kinetics were determined by turbidimetry.