Publications by authors named "Anne-Claire Strzelecki"
Article Synopsis
- Diagnosing infectious diseases is complicated, and this study aimed to analyze diagnostic uncertainty (DU) in patients with positive blood cultures (PBC) and assess how it affects antibiotic treatment and patient outcomes.
- The research involved real-time communication of PBC results to infectious disease specialists, who reviewed patient charts and provided treatment advice, highlighting that 47% of cases experienced diagnostic uncertainty.
- Findings indicated that DU was linked to higher hospitalization rates, increased use of broad-spectrum antibiotics, and a greater likelihood of poor outcomes, including death during hospitalization.
Mutations in DNMT3A encoding DNA methyltransferase 3A were recently described in patients with acute myeloid leukemia. To assess their prognostic significance, we determined the mutational status of DNMT3A exon 23 in 288 patients with AML excluding acute promyelocytic leukemia, aged from 18 to 65 years and treated in Toulouse University Hospital. A mutation was detected in 39 patients (13.
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- Human leukemic stem cells (SL-ICs), identified in acute myelogenous leukemia (AML), are rare and can be found among various lineage marker-expressing cells, challenging the traditional cancer stem cell model!
- Using NOD/SCID/IL2Rγc-deficient mice for xenotransplantation, the study confirmed SL-ICs' presence in lineages (Lin+ cells) and indicated that these cells retain their ability to self-renew in secondary transplants!
- The findings highlight that AML stem cells display a greater phenotypic diversity than previously thought, suggesting that their characteristics are more plastic and not strictly limited to primitive hematopoietic cell markers.