The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development.

Correct brain wiring depends on reliable synapse formation. Nevertheless, signaling codes promoting synaptogenesis are not fully understood. Here, we report a spinogenic mechanism that operates during neuronal development and is based on the interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) with the synaptic cell adhesion molecule neuroplastin.

A complex of Neuroplastin and Plasma Membrane Ca ATPase controls T cell activation.

The outcome of T cell activation is determined by mechanisms that balance Ca influx and clearance. Here we report that murine CD4 T cells lacking Neuroplastin (Nptn ), an immunoglobulin superfamily protein, display elevated cytosolic Ca and impaired post-stimulation Ca clearance, along with increased nuclear levels of NFAT transcription factor and enhanced T cell receptor-induced cytokine production. On the molecular level, we identified plasma membrane Ca ATPases (PMCAs) as the main interaction partners of Neuroplastin.

Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects.

Objective: Endocannabinoid system (ECS) activation promotes obesity-associated metabolic disease. Increased dietary fat intake increases blood endocannabinoids and alters adipose and skeletal muscle ECS gene expression in human.

Methods: Two weeks isocaloric low- (LFD) and high-fat diets (HFD) in obese (n = 12) and normal-weight (n = 17) subjects in a randomized cross-over study were compared.

SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations.

Chemical synapses are highly specialized cell-cell contacts for communication between neurons in the CNS characterized by complex and dynamic protein networks at both synaptic membranes. The cytomatrix at the active zone (CAZ) organizes the apparatus for the regulated release of transmitters from the presynapse. At the postsynaptic side, the postsynaptic density constitutes the machinery for detection, integration, and transduction of the transmitter signal.