Publications by authors named "Anne-Cathrine Shalmi"
Article Synopsis
- The study aimed to investigate whether mitochondrial haplogroups influence the risk or severity of preeclampsia in pregnant women.
- After analyzing samples from 235 control and 78 preeclamptic pregnancies in Denmark, no significant links were found between haplogroups and preeclampsia.
- The researchers concluded that while common mitochondrial haplogroups do not appear to play a role, there may still be less common variations that warrant further investigation.
The serum adiponectin/leptin ratio (A/L ratio) is a surrogate marker of insulin sensitivity. Pre-eclampsia (PE) is associated with maternal metabolic syndrome and occasionally impaired fetal growth. We assessed whether the A/L ratio in first-trimester maternal serum was associated with PE and/or birth weight.
View Article and Find Full Text PDFBackground: Placental protein-13 (PP13) is involved in placental invasion and has been suggested as a maternal serum marker of preeclampsia (PE) development. However, the discriminatory ability of PP13 in first trimester has not been completely clarified.
Methods: PP13 was measured in first trimester (week 10+3-13+6) maternal serum from 120 PE pregnancies and 267 control pregnancies and was correlated with clinical parameters.
Article Synopsis
- The study aimed to determine the relationship between resistin levels in early pregnancy and insulin resistance or preeclampsia (PE).
- Involving 285 normal pregnancies and 123 PE cases, researchers found that resistin levels negatively correlated with the severity of PE but showed no link to insulin resistance or other measured factors.
- The findings suggest that lower resistin levels are associated with severe cases of PE in the first trimester, indicating that inflammation and insulin sensitivity do not account for this reduction.
Objectives: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark.
Methods: Fetuses and infants diagnosed with CHD in the period 01.
Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied.
Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied.
Objectives: To establish the distribution of serological and ultrasound first-trimester Down syndrome markers in twins and identify correlations of significance for risk calculation.
Methods: Nuchal translucency (NT), PAPP-A and betahCG data were extracted from 181 twin pregnancies (31 mono- and 150 dichorionic) with a normal outcome. All pregnancies were consecutively and prospectively included and examined in the Copenhagen First-Trimester Study.
Objectives: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.
Methods: We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum.
Objectives: To estimate the screening performance of different combinations of first- and second-trimester markers, including a new marker, the proform of eosinophil major basic protein (proMBP).
Methods: The population comprised 195 singleton pregnancies with a normal outcome enrolled in the Copenhagen First Trimester Study, in which a serum sample was available from both the first and the second trimester. The performance of different marker combinations was estimated by receiver-operator-characteristics (ROC) analysis using a Monte Carlo simulation and distributions of log(10)MoM markers and their correlations, derived from our normal material and Down syndrome cases from the literature.
The influence of fetal gender on the level in the first trimester of the serological markers alpha-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (betahCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free betahCG, being 16% higher for female than for male fetuses.
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