Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification.

Background: Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence, with the aim of improving patient stratification.

Methods: We conducted a case-control study within a cohort of PCa patients recruited between 1996 and 2015.

Environmental risk assessment of ivermectin: A case study.

The veterinary parasiticide ivermectin was selected as a case study compound within the project ERAPharm (Environmental Risk Assessment of Pharmaceuticals). Based on experimental data generated within ERAPharm and additional literature data, an environmental risk assessment (ERA) was performed mainly according to international and European guidelines. For the environmental compartments surface water, sediment, and dung, a risk was indicated at all levels of the tiered assessment approach.

Long-term sorption and desorption of sulfadiazine in soil: experiments and modeling.

Antibiotics, such as sulfadiazine (SDZ), may enter arable soil by spreading of manure of medicated husbandry or directly by the excrement of grazing animals. Knowledge of the fate of antibiotics in soils is crucial for assessing the environmental risk of these compounds, including possible transport to ground water. Kinetic sorption of (14)C-labeled SDZ (4-amino-N-pyrimidin-2-yl-benzenesulfonamide) was investigated using the batch technique.

Environmental risk assessment of human pharmaceuticals in the European Union: A case study with the β-blocker atenolol.

β-Adrenergic receptor blockers (β-blockers) are applied to treat high blood pressure, ischemic heart disease, and heart rhythm disturbances. Due to their widespread use and limited human metabolism, β-blockers are widely detected in sewage effluents and surface waters. β-Adrenergic receptors have been characterized in fish and other aquatic animals, so it can be expected that physiological processes regulated by these receptors in wild animals may be affected by the presence of β-blockers.

Transport of sulfadiazine in soil columns: experiments and modelling approaches.

Antibiotics, such as sulfadiazine, reach agricultural soils directly through manure of grazing livestock or indirectly through the spreading of manure or sewage sludge on the field. Knowledge about the fate of antibiotics in soils is crucial for assessing the environmental risk of these compounds, including possible transport to the groundwater. Transport of (14)C-labelled sulfadiazine was investigated in disturbed soil columns at a constant flow rate of 0.