Publications by authors named "Anne V Eberhard"
Article Synopsis
- Statins, which are medicines usually used to lower cholesterol, also help fight inflammation in blood vessels, but how they do this is still not completely understood.
- Researchers used special tests to find out that statins help remove dying cells from the body by blocking a signal called CD47, which tells the immune system not to eat those cells.
- Studies on samples from people show that statins work similarly in humans, suggesting they could be important for new treatments that help prevent heart problems.
Background The promise of precision population health includes the ability to use robust patient data to tailor prevention and care to specific groups. Advanced analytics may allow for automated detection of clinically informative subgroups that account for clinical, genetic, and environmental variability. This study sought to evaluate whether unsupervised machine learning approaches could interpret heterogeneous and missing clinical data to discover clinically important coronary artery disease subgroups.
View Article and Find Full Text PDFThis national cohort study examines changes in the number of vascular surgical procedures completed in the US before and during the COVID-19 pandemic.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to see if F-fluorodeoxyglucose-positron emission tomography (FDG-PET/CT) could detect changes in vulnerable atherosclerotic plaques in a mouse model following treatment.
- - Researchers fed ApoE mice a high-fat diet to create plaques and then treated them with various therapies for 9 weeks, finding that FDG-PET/CT successfully identified changes in plaque stability post-treatment.
- - The findings indicate that FDG-PET/CT can noninvasively identify unstable atherosclerotic plaques and monitor their therapeutic responses, potentially aiding in drug discovery and assessment.
Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques expand primarily via the accumulation of cholesterol and inflammatory cells.
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