Publications by authors named "Anne Timper"
Background: Xenon (Xe) is neuroprotective when given 1h after cardiopulmonary resuscitation (CPR). Here, we investigated if an earlier administration of Xe or isoflurane (Iso) would also reduce neurological dysfunction.
Methods: 10 min after CPR from 8 min of cardiac arrest 21 pigs were randomized to three groups (n=7/group) and then ventilated for 1h with gas mixtures as follows: (1) control: 30% O(2)+70% N(2); (2) Iso: 30% O(2)+69% N(2)+1% Iso; (3) Xe: 30% O(2)+70% Xe.
Objective: Neurologic outcome after cardiopulmonary resuscitation from cardiac arrest carries a poor prognosis and treatment options to ameliorate brain damage are limited.
Design: Report of two protocols investigating the effects of xenon (Xe) and isoflurane (Iso) in a porcine model of prolonged cardiac arrest and subsequent cardiopulmonary resuscitation on functional neurologic outcomes.
Setting: Prospective, randomized, laboratory animal study.
Article Synopsis
- The study aimed to explore the potential benefits of xenon treatment in reducing brain damage after cardiopulmonary resuscitation following cardiac arrest in pigs.
- Using a randomized design, 24 male pigs were resuscitated and then divided into groups receiving either xenon or untreated nitrogen for one to five hours.
- The results indicated that xenon treatment led to significantly less brain cell damage and inflammation, resulting in better neurocognitive and neurological outcomes shortly after resuscitation.
Objective: To test the feasibility of a neurocognitive test based on operant conditioning in a porcine model of cardiac arrest and cardiopulmonary resuscitation. Furthermore, to characterize the influence of different durations of cardiac arrest on cognitive performance and the accompanying neurohistopathological changes.
Design: Randomized controlled laboratory animal study.