The Xen gel stent is a minimally invasive glaucoma surgical implant designed to decrease intraocular pressure (IOP) by creating an aqueous outflow path into the subconjunctival space. Since FDA approval, it has demonstrated good safety and efficacy data; however, there are multiple reports of Xen stent occlusions with debris from the anterior chamber. Herein, we report a case of a Descemet's membrane Xen stent occlusion in a 67-year-old woman with a past medical history of primary open angle glaucoma who underwent Xen stent placement through the ab externo approach.
View Article and Find Full Text PDFObjective: To investigate preclinical data regarding the efficacy and biocompatibility of a bispecific protein, RO-101, with effects on VEGF-A and angiopoietin-2 (Ang-2) for use in retinal diseases.
Design: Experimental study.
Subjects: Brown Norway rats and New Zealand White Cross rabbits.
Purpose: To investigate the relationship between limited English proficiency (LEP) and diabetic retinopathy (DR) in patients presenting for cataract surgery.
Methods: This is a retrospective observational study of patients who underwent cataract surgery between January 2014 and February 2020. Patients who self-identified as needing or preferring an interpreter were defined as having LEP.
Purpose: To determine differences in cataract surgery outcomes between English proficient (EP) and limited English proficiency (LEP) patients.
Setting: Sue Anschutz-Rodgers Eye Center, Aurora, Colorado.
Design: Retrospective.
Background: Non-infectious intermediate, posterior, and panuveitis (NIIPPU) represent a heterogenous collection of autoimmune and inflammatory disorders isolated to or concentrated in the posterior structures of the eye. Because NIIPPU is typically a chronic condition, people with NIIPPU frequently require treatment with steroid-sparing immunosuppressive therapy. Methotrexate, mycophenolate, cyclosporine, azathioprine, and tacrolimus are non-biologic, disease-modifying antirheumatic drugs (DMARDs) which have been used to treat people with NIIPPU.
View Article and Find Full Text PDFPurpose: To investigate the risk of unexpected refractive prediction error after cataract surgery in patients with thyroid eye disease (TED) at the University of Colorado.
Patients And Methods: A retrospective observational study was performed using records of patients who underwent cataract surgery (2014 to 2018) who were included in a Cataract Surgery Outcomes database. Any patient with documentation of thyroid eye disease (TED) in the medical record was classified as TED.