Exercise training improves participation in persons with multiple sclerosis: A systematic review and meta-analysis.

Background: Although previous studies have examined the effects of exercise training on other International Classification of Functioning, Disability and Health (ICF) component levels in persons with multiple sclerosis (MS), the effects of exercise training on participation remain unclear. The objectives of this review were to: (1) characterize systematically the use of outcome measures that capture participation in exercise training studies; (2) quantify the effect of exercise training on participation in persons with MS.

Methods: A search of 6 electronic databases (CINAHL, SPORTDiscuss, Embase, MEDLINE, Cochrane Central, and Scopus) was conducted to identify controlled and noncontrolled trials involving exercise training and participation in persons with MS.

Lower extremity muscle strength across the adult lifespan in multiple sclerosis: Implications for walking and stair climbing capacity.

Introduction: Persons with multiple sclerosis (pwMS) accumulate impairments in muscle strength and limitations in physical function as the disease progresses. The same symptoms are seen in the biological process of aging (years of age > 60 years). Nonetheless, no previous studies have examined the combined effects of aging and multiple sclerosis (MS) in regards to lower extremity muscle strength concomitant with physical function (e.

Physical activity is associated with neuromuscular and physical function in patients with multiple sclerosis independent of disease severity.

Purpose: Examine the association between physical activity and neuromuscular and physical function in patients with multiple sclerosis when also considering disease severity.

Methods: 91 patients with multiple sclerosis were enrolled. Assessments included physical activity by 7-day thigh-worn accelerometry, knee extensor neuromuscular function by dynamometry (maximal isometric muscle strength, rate of force development (0-50 ms)), and physical function by 5× sit-to-stand, 2-min walk test, and timed 25 ft walk test.