Publications by authors named "Anne Sophie Lixenfeld"
Background: Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically protective through enhanced FcγRIIIa binding, can also trigger exacerbated pro-inflammatory responses in severe COVID-19. We investigated if the BNT162b2 SARS-CoV-2 mRNA also induced afucosylated IgG responses.
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- COVID-19 is linked to significant metabolic disruptions, showing a specific serum profile associated with severe lipid abnormalities when compared to healthy individuals.
- In a study analyzing 482 serum samples, COVID-19 patients displayed increased levels of certain lipoproteins while having decreased cholesterol, indicating altered metabolic status.
- The distinct metabolic profile of COVID-19 patients sets them apart not only from healthy controls but also from other serious conditions like cardiogenic shock, suggesting unique implications for lipid metabolism in the disease.