Publications by authors named "Anne Sophie Hoffbeck"
Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and mediate its repair. Although many proteins have been implicated in these processes, only recent studies have revealed how they operate in the context of high-ordered chromatin structure.
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- SPOC1 (PHF13) is essential for chromatin structure and testicular stem-cell differentiation; it also plays a role in DNA double-strand break repair in ovarian cancer.
- SPOC1 is involved in the DNA damage response, affecting the speed and pathways of repair, specifically enhancing non-homologous end-joining (NHEJ) and hindering homologous recombination (HR).
- SPOC1 influences the activity and association of various chromatin-related proteins, ultimately regulating the cellular response to DNA damage and contributing to radiosensitivity and resistance.