[Effectiveness of "threshold" in the management of ovarian cancer: A review of the literature].

Objective: The "Institut national du cancer" has established since 2007 a minimum threshold of 20 patients per year per center to treat patients with gynecologic cancer. This review aims to assess whether the literature data validate this approach, and specifically for ovarian cancer.

Methods: A search of the MEDLINE database was conducted, to reference all relevant articles evaluating one hand the links between the survival of patients with ovarian cancer and the average volume of patients per center and by operator; and secondly the relationship between quality of oncological surgery and these volumes.

[Epidemiology and risk factors for cancer of the uterus].

Cancers of the uterus correspond to cervical cancers and uterine corpus cancers. Cervical cancer is common among young women, especially in immunocompromised populations. Its carcinogenesis is induced by the human papilloma virus (HPV).

Pregnancy stimulates tumor angiogenesis in breast carcinoma.

The mechanisms responsible for the poor prognosis of pregnancy-associated breast cancer (PABC) remain not well-understood. We studied angiogenesis and lymphangiogenesis as they are known prognostic factors in breast cancer. We conducted a case control study of breast cancer comparing women with and without PABC matched for age and histological parameters.

Evaluation of a method of predicting lymph node metastasis in endometrial cancer based on five pre-operative characteristics.

Objective: We recently developed an algorithm based on five clinical and pathological characteristics to predict lymph node (LN) metastasis in endometrial cancer. The aim of this study was to evaluate the accuracy of using this algorithm with preoperative characteristics.

Study Design: In this retrospective multicenter study, we evaluated the accuracy of using an algorithm to predict LN metastasis using preoperative tumor characteristics provided by endometrial sampling pathological characteristics (histological subtype and grade) and by magnetic resonance imaging (MRI) for primary site tumor extension.

A nomogram for predicting lymph node metastasis of presumed stage I and II endometrial cancer.

Objective: Our objective was to develop a nomogram based on pathological hysterectomy characteristics to provide a more individualized and accurate estimation of lymph node metastasis in endometrial cancer.

Study Design: Data from the Surveillance, Epidemiology, and End Results database for 18,294 patients who underwent hysterectomy and lymphadenectomy were analyzed. A multivariate logistic regression analysis of selected prognostic features was performed, and a nomogram to predict lymph node metastasis was constructed.

Pregnancy-associated breast cancers: do they differ from other breast cancers in young women?

The impact of pregnancy in the physiopathology of pregnancy-associated breast cancer (PABC) is still unclear. We compared the characteristics of PABCs and breast cancers not associated with pregnancy (non-PABCs) in terms of their loco-regional invasion and histological phenotype. We conducted a retrospective chart review on women less than 43 years of age treated for breast cancer from January 1, 2004 to December 31, 2010.

The survival impact of systematic lymphadenectomy in endometrial cancer with the use of propensity score matching analysis.

Objective: We sought to evaluate whether patients with endometrial cancer in the Surveillance, Epidemiology, and End Results database who underwent lymphadenectomy demonstrate improved survival.

Study Design: The study population comprised 50,969 patients. The 3-year cause-specific survival was tested by using propensity score matching (PSM) analysis.