Topical Medications for Atopic Dermatitis and Effects on Increasing Lymphoma Risks.

Atopic dermatitis is an immune-mediated skin condition that causes relapsing, pruritic skin lesions. Flares of this disease are often treated with topical corticosteroids; however, the use of these drugs can cause unwanted side effects, such as cutaneous atrophy and impaired wound healing. To minimize these common side effects, severe forms of this disease have been treated with topical calcineurin inhibitors, which previously had no known long-term side effects.

Genetic Analysis of Methyl Anthranilate, Mesifurane, Linalool, and Other Flavor Compounds in Cultivated Strawberry ( × ).

The cultivated strawberry ( × ) is an economically important fruit crop that is intensively bred for improved sensory qualities. The diversity of fruit flavors and aromas in strawberry results mainly from the interactions of sugars, acids, and volatile organic compounds (VOCs) that are derived from diverse biochemical pathways influenced by the expression of many genes. This study integrates multiomic analyses to identify QTL and candidate genes for multiple aroma compounds in a complex strawberry breeding population.

Influenza spread on context-specific networks lifted from interaction-based diary data.

Studying the spread of infections is an important tool in limiting or preventing future outbreaks. A first step in understanding disease dynamics is constructing networks that reproduce features of real-world interactions. In this paper, we generate networks that maintain some features of the partial interaction networks that were recorded in an existing diary-based survey at the University of Warwick.

The Genetics of Differential Gene Expression Related to Fruit Traits in Strawberry ().

Octoploid strawberry () is a major specialty crop under intense annual selection for traits relating to plant vigor and fruit quality. Most functional validation experiments rely on transgenic or transient gene expression assays in the mature receptacle. These findings are not typically translatable to breeding without identifying a natural genetic source of transcript level variation, and developing reliable markers for selection in octoploids.

Comparing Treatment Strategies for Stage I Small-cell lung Cancer.

Introduction: The diagnosis of stage I small-cell lung cancer (SCLC) is increasing in incidence with the advent of low-dose screening computed tomography. Surgery is considered the standard of care but there are very few data to guide clinical decision-making. The purpose of this study was to compare outcomes for patients receiving definitive surgery, stereotactic body radiation therapy (SBRT), or external beam radiation therapy (EBRT) for stage I SCLC.

Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study.

Objective: To test the hypothesis that an 8-year intensive lifestyle intervention (ILI) suppresses aging-dependent changes in regional lean mass (LM) and fat mass (FM) among people with overweight/obesity and type 2 diabetes.

Methods: Regional body composition was measured by dual-energy X-ray absorptiometry within a subset of 1,019 volunteers (45-75 years old) in the Look AHEAD study randomized to ILI or diabetes support and education (DSE). The ILI goal was to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake.

Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study.

Objective: To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years.

Methods: Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake.

Collaborating to combat childhood obesity.

Despite outstanding advances in children's health over the past several decades, rates of childhood obesity are near epidemic proportions. This paper highlights foundations' efforts to fight childhood obesity by convening organizations and effecting change at many levels of the community.

The path to policy change: practical steps and lessons from health funders.

As part of its continuing mission to serve trustees and staff of health foundations and corporate giving programs, on November 3, 2005, Grantmakers In Health (GIH) convened nearly 80 grantmakers and a diverse group of individuals with expertise in different types of public policy work to discuss the challenges and opportunities for health funders who seek to bring about change in federal, state, and local public policies. The program was designed to address funders' desire to go beyond the basics of funding public policy work and to learn from peers and others about how to improve the effectiveness of their public policy efforts. It was structured as a series of small-group discussions on key topics including advocacy infrastructure, communications, community organizing, data development and analysis, evaluation, working with foundation boards, and working with policymakers.

Child health: fertile ground for philanthropic investment.

Children and youth are the focus for many foundations and corporate-giving programs working in the health field. Total foundation giving targeted to children and youth more than doubled during the late 1990s; in 2000, health accounted for 25 percent of philanthropic dollars invested in this population. This funding covers a broad range of child health issues but clusters in four key areas-promoting healthy behavior, improving access to care and expanding insurance coverage, strengthening mental health services, and addressing the broader determinants of health.

Factors regulating collagen synthesis and degradation during second-intention healing of wounds in the thoracic region and the distal aspect of the forelimb of horses.

Objective: To determine significant molecular and cellular factors responsible for differences in second-intention healing in thoracic and metacarpal wounds of horses.

Animals: 6 adult mixed-breed horses.

Procedure: A full-thickness skin wound on the metacarpus and another such wound on the pectoral region were created, photographed, and measured, and tissue was harvested from these sites weekly for 4 weeks.