Publications by authors named "Anne Petz"
Dysregulated extracellular matrix (ECM) is a hallmark of adverse cardiac remodeling after myocardial infarction (MI). Previous work from our laboratory suggests that synthesis of the major ECM component hyaluronan (HA) may be beneficial for post-infarct healing. Here, we aimed to investigate the mechanisms of hyaluronan synthase 3 (HAS3) in cardiac healing after MI.
View Article and Find Full Text PDFRationale: Immediate changes in the ECM (extracellular matrix) microenvironment occur after myocardial ischemia and reperfusion (I/R) injury.
Objective: Aim of this study was to unravel the role of the early hyaluronan (HA)-rich ECM after I/R.
Methods And Results: Genetic deletion of Has2 and Has1 was used in a murine model of cardiac I/R.
Diabetic patients are at a greater risk of heart failure due to diabetic cardiomyopathy and worsened outcome post-myocardial infarction. While the molecular mechanisms remain unclear, fibrosis and chronic inflammation are common characteristics of both conditions. Diabetes mellitus (types I and II) results in excessive hyaluronan (HA) deposition in vivo, and hyperglycemia stimulates HA synthesis for several cell types in vitro.
View Article and Find Full Text PDFArticle Synopsis
- Insulin-like growth factor 1 (IGF1) plays a crucial role in enhancing growth and metabolism in cells and demonstrates cardio-protective properties after acute myocardial infarction (AMI).
- A study showed that short-term IGF1 treatment improved heart function, reduced scar size, and increased capillary density in heart tissue over several weeks following AMI.
- The protective effects of IGF1 were linked to its impact on myeloid cells and the promotion of an anti-inflammatory response in macrophages, suggesting it helps modulate inflammation to preserve heart function after injury.