Publications by authors named "Anne Parra"
Toward a Plasmon-Based Biosensor throughout a Thermoresponsive Hydrogel.
ACS Appl Polym Mater
November 2024
This study investigates the potential of thermoresponsive hydrogels as innovative substrates for future in vitro diagnostic (IVD) applications using AVAC technology, developed and patented by the Mecwins biomedical company. In order to convert the hydrogel in a substrate compatible with AVAC technology, the following prerequisites were established: (1) the hydrogel layer needs to be permeable to gold nanoparticles (AuNPs), and (2) the optical properties of the hydrogel should not interfere with the detection of AuNPs with AVAC technology. These two key aspects are evaluated in this work.
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- Plasmonic biosensors are gaining popularity in scientific and medical fields due to their ability to detect biomolecular and chemical interactions with high sensitivity and precision.
- One of the ongoing challenges is accurately detecting low molecular weight substances, like free cholesterol, which is crucial for diagnostic tools but difficult due to its size and properties.
- The study introduces a new approach using a cholesterol-binding peptide along with plasmonic optical readout that achieves a very low detection limit and operates effectively in a specific concentration range, potentially enhancing cholesterol measurement methods.