Anaphylaxis in children and adolescents: The European Anaphylaxis Registry.

Background: Anaphylaxis in children and adolescents is a potentially life-threatening condition. Its heterogeneous clinical presentation and sudden occurrence in virtually any setting without warning have impeded a comprehensive description.

Objective: We sought to characterize severe allergic reactions in terms of elicitors, symptoms, emergency treatment, and long-term management in European children and adolescents.

Anaphylaxis to general anesthetics.

The incidence of hypersensitivity reactions to anesthetics is estimated 1 in 13,000 anesthetics up to 1 in 3,180. The rate of mortality ranges between 3 and 9%. 90% of reactions appear at anesthesia induction.

Gastrointestinal allergy in adults.

The prevalence of food allergy reaches 3% in the adult population. Chronic gastrointestinal allergy is a rare entity: 4.2% of food allergies in adults, and represents 3.

T cell-mediated reactions to iodinated contrast media: evaluation by skin and lymphocyte activation tests.

Background: In addition to immediate reactions, late adverse reactions to iodinated contrast media (ICM) were reported in 2% to 5% of patients exposed to ICM and, as a consequence, have recently gained more attention. A few well-documented case reports postulate a hypersensitivity mechanism.

Objective: The aim of this study is to demonstrate a T cell-mediated mechanism to the ICM by using in vitro and ex vivo tests.

Chloroquine hypersensitivity syndrome.

Chloroquine is widely used for antimalarial prophylaxis. We report the first case of delayed hypersensitivity syndrome associated with fever, digestive symptoms, bullous eruption, and eosinophilia due to chloroquine as proven by drug history and a positive patch-test for chloroquine.