Mortality Benefit Among Primary Prevention Implantable Cardioverter-Defibrillator Recipients on Contemporary Heart Failure Treatment.

Background: Past clinical trials have shown the benefit of implantable cardioverter-defibrillators (ICDs) for reducing sudden cardiac death in at-risk patients. However, heart failure management and ICD technology have changed since these trials were first published. An updated assessment of ICD mortality benefit is needed.

Simple Fabrication Method for Mixed Matrix Membranes with in Situ MOF Growth for Gas Separation.

Metal organic framework (MOF)/polymer composite membranes are of interest for gas separations, as they often have performance that exceeds the neat polymer. However, traditional composite membranes, known as mixed matrix membranes (MMMs), can have complex and time-consuming preparation procedures. The MOF and polymer are traditionally prepared separately and require priming and mixing to ensure uniform distribution of particles and compatibility of the polymer-particle interface.

Continuous Flow Processing of ZIF-8 Membranes on Polymeric Porous Hollow Fiber Supports for CO Capture.

We have utilized an environmentally friendly synthesis approach for the accelerated growth of a selective inorganic membrane on a polymeric hollow fiber support for postcombustion carbon capture. Specifically, continuous defect-free ZIF-8 thin films were grown and anchored using continuous flow synthesis on the outer surface of porous supports using water as solvent. These membranes demonstrated CO permeance of 22 GPU and the highest reported CO/N selectivity of 52 for a continuous flow synthesized ZIF-8 membrane.

Separation of carbon dioxide from flue gas by mixed matrix membranes using dual phase microporous polymeric constituents.

This study presents the fabrication of a new mixed matrix membrane using two microporous polymers: a polymer of intrinsic microporosity PIM-1 and a benzimidazole linked polymer, BILP-101, and their CO separation properties from post-combustion flue gas. 17, 30 and 40 wt% loadings of BILP-101 into PIM-1 were tested, resulting in mechanically stable films showing very good interfacial interaction due to the inherent H-bonding capability of the constituent materials. Gas transport studies showed that BILP-101/PIM-1 membranes exhibit high CO permeability (7200 Barrer) and selectivity over N (15).

An ultra-microporous organic polymer for high performance carbon dioxide capture and separation.

Rational design concepts were used to prepare a novel porous benzimidazole-linked polymer (BILP-101) in a simple one-pot reaction. BILP-101 has exhibited ultra-microporosity (0.54 nm), very high CO2 uptake (∼1 mmol g(-1), 4 wt%, 0.

Synthesis and bioconversions of formestane.

In an effort to generate new steroidal aromatase inhibitors, formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) was biotransformed by Rhizopus oryzae to yield the known 4β,5α-dihydroxyandrostane-3,17-dione as the major product (5) and bioconverted by Beauveria bassiana to afford the known reduced 4,17β-dihydroxyandrost-4-en-3-one (6) and 3α,17β-dihydroxy-5β-androstan-4-one (7) and the new 4,11α,17β-trihydroxyandrost-4-en-3-one (8). All the metabolites showed more potent activities than their parent congener in the aromatase and MCF-7 breast cancer assays. The bioactivities and structural elucidation of these metabolites as well as the semisynthesis of formestane (1) from testosterone (2) are reported herein.

Fabrication of oriented silver-functionalized RPM3 films for the selective detection of olefins.

Oriented thin films of a flexible, luminescent, metal organic framework (MOF), [Zn2(bpdc)2(bpee)·2DMF] (bpdc = 4,4'-biphenyldicarboxylate; bpee = 1,2-bipyridylethylene), also known as RPM3, were prepared on glass via pulsed laser deposition (PLD) followed by a solvothermal treatment. RPM3 thin films were then functionalized with AgNO3 by forming a π complex with the bpee linker. The reversible binding of olefins such as propylene and 1-hexene to the Ag(+) functionalized RPM3 thin film was monitored by fluorescence spectroscopy.

Tuning the gate opening pressure of Metal-Organic Frameworks (MOFs) for the selective separation of hydrocarbons.

Separation of hydrocarbons is one of the most energy demanding processes. The need to develop materials for the selective adsorption of hydrocarbons, under reasonable conditions, is therefore of paramount importance. This work unveils unexpected hydrocarbon selectivity in a flexible Metal-Organic Framework (MOF), based on differences in their gate opening pressure.