Publications by authors named "Anne M Zimmer"
Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation.
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- Psalmotoxin 1 is a peptide from the South American tarantula that effectively reduces various types of pain in rodents, including thermal and neuropathic pain.
- It works by blocking a specific ion channel (acid-sensing ion channel 1a), which activates the body's natural pain-relieving system (endogenous enkephalin pathway).
- The pain-relief effects of Psalmotoxin 1 can be inhibited by certain opioid receptor blockers, and are absent in genetically modified mice lacking the Penk1 gene.