J Allergy Clin Immunol
December 2006
Background: The immunologic response to immunotherapy with dog extract is not well characterized.
Objective: The purpose of this study was to examine the immunologic response to 3 doses of dog extract expressed as their Can f 1 content.
Methods: Cluster immunotherapy was administered to 28 patients with dog allergy who were randomly assigned to 1 of 4 treatment arms: placebo or acetone-precipitated extract containing 0.
Background: The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy.
Objective: We sought to examine whether persistent eosinophilia would be accompanied by an increased FENO level despite steroid therapy in patients with severe refractory asthma (SRA) as manifestations of steroid resistance.
Methods: Subjects with SRA, subjects with mild-moderate asthma, and healthy control subjects had FENO measured, followed by endobronchial biopsy and bronchoalveolar lavage.
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