Publications by authors named "Anne Lundager Madsen"
Article Synopsis
- The study explores how host genome variants influence oral microbial communities, linking the mouth's bacteria to both oral and overall health in 610 Danish adults.
- Researchers identified six specific single nucleotide polymorphisms (SNPs) associated with varying abundances of oral bacteria and found that one SNP significantly exceeded the study's significance threshold.
- The findings suggest a complex relationship between genetics, oral microbiota, and metabolic health, indicating a need for combined studies in these areas to better understand health outcomes.
Aging has been associated with a changed composition and function of the gut microbiota (GM). Here, we investigate the effects of the multi-strain probiotic HOWARU Restore on GM composition and function in seniors. Ninety-eight healthy adult volunteers aged ≥75 years were enrolled in a randomised, double-blinded intervention (NCT02207140), where they received HOWARU Restore (10 CFU) or the placebo daily for 24 weeks, with 45 volunteers from each group completing the intervention.
View Article and Find Full Text PDFBackground: Frequent binge drinking is a known contributor to alcohol-related harm, but its impact on systemic and hepatic inflammation is not fully understood. We hypothesize that changes in immune markers play a central role in adverse effects of acute alcohol intake, especially in patients with early liver disease.
Aim: To investigate the effects of acute alcohol intoxication on inflammation-related markers in hepatic and systemic venous plasma in people with alcohol-related liver disease (ArLD), non-alcoholic fatty liver disease (NAFLD) and healthy controls.
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.
J Clin Endocrinol Metab
January 2021
Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.
Objective: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies.