Publications by authors named "Anne Lieke Burgers"
Stem Cell Res Ther
November 2024
Article Synopsis
- - Huntington's disease (HD) is a genetic disorder that leads to the loss of specific neurons in the brain, causing motor dysfunction, and researchers are exploring cell replacement therapies to restore neuronal function.
- - The study focuses on creating human lateral ganglionic eminence precursors (hiLGEPs) from adult human skin cells through a process called direct reprogramming, which was evaluated for its ability to differentiate into functional neurons.
- - Results showed that hiLGEPs could be successfully produced and transplanted into rats with HD-like symptoms, demonstrating their potential to survive, integrate, and contribute to neuronal function over a 14-week period.
