Anticoagulant-associated adverse drug reactions in 2013-15.

Background: The aim of this study was to obtain a better insight into the adverse effects profiles of the new direct-acting oral anticoagulants (DOACs).

Material And Method: A review was undertaken of all reports of adverse effects for warfarin, dabigatran, rivaroxaban and apixaban reported to the regional medicines information and pharmacovigilance centres (RELIS) in the period June 2013-May 2015.

Results: Approximately 65 000 persons used direct-acting oral anticoagulants and 80 000 used warfarin in the period of the study.

Prescribing of NOACs has outnumbered warfarin: exploring how physicians choose anticoagulant treatments.

Purpose: The development of non-vitamin K-dependent oral anticoagulants (NOACs) is a new alternative to treatment with warfarin. The purpose of this study was to explore drug prescription decisions of NOACs or warfarin from hospital physicians in cardiovascular departments.

Methods: A qualitative study with focus group interviews was conducted in three different hospitals.

How are drug regimen changes during hospitalisation handled after discharge: a cohort study.

Objectives: To investigate drug regimen changes during hospitalisation and explore how these changes are handled after patients are transferred back into the care of their general practitioners (GPs).

Design: Cohort study.

Setting: Patients in this multicentre study had undergone at least one change in their drug regimens at discharge from the general medicine departments at six hospitals in Norway.