Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines.

Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na/K-ATPase and to promote several biological activities, including anti-inflammatory activity. However, there are still no reports in the literature about inflammation and marinobufagenin, a cardiotonic steroid from the bufadienolide family endogenously found in mammals. Therefore, the aim of this work was to analyze, and , the role of marinobufagenin in acute inflammation.

Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain.

[This corrects the article on p. 895 in vol. 8, PMID: 29176951.

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain.

Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the binding to its receptor, the Na/K-ATPase, on target cells.