In vivo pharmacokinetics of a gentamicin-loaded collagen sponge in acute periprosthetic infection: serum values in 19 patients.

Background: The in vivo pharmacokinetics of gentamycin- loaded collagen fleeces in humans have not been described in the current literature. We therefore analyzed in vivo pharmacokinetics of these fleeces when used in the treatment of periprosthetic infections.

Patients And Methods: Gentamycin concentrations were measured in 19 consecutive patients with an acute periprosthetic infection.

Excellent results from proximally HA-coated femoral stems with a minimum of 6 years follow-up: a prospective evaluation of 100 patients.

Background: There have been few reports on the mid- and long-term follow-up results of the proximally HA-coated femoral stem. We evaluated this type of stem prospectively, with 6-12 years of follow-up.

Methods: The survival rate, Harris hip score and radiographic features of 106 hips in 100 consecutive patients were evaluated.

Toxic serum gentamicin levels after the use of gentamicin-loaded sponges in infected total hip arthroplasty.

Background: At our clinic, total hip arthroplasties with an acute postoperative infection are treated with surgical debridement and application of several gentamicin-loaded sponges, each with an equivalent of 130 mg gentamicin. We studied the possible systemic effect of this local application of gentamicin.

Patients And Methods: All 12 patients treated during 1997-2001 were included.